Last update
9/7/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 1 Capsule
Serving Per Container: 90
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol)
250 mcg(10,000 IU)
1250%
Top Medical Research Studies
9
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
Read More
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
Read More
8
Our investigation centered around the link between vitamin D levels and cholesterol, particularly focusing on high cholesterol. We analyzed data from nearly 48,000 outpatients to see how two forms of vitamin D—25-hydroxyvitamin D and 1,25-dihydroxyvitamin D—relate to various cholesterol parameters, such as LDL (the "bad" cholesterol), HDL (the "good" cholesterol), and total cholesterol levels.
We discovered that higher levels of 25(OH)D are connected with lower LDL and total cholesterol levels across the board. This relationship was especially strong among men over 50. Interestingly, the pattern varied for women; they showed a positive correlation with LDL and total cholesterol before age 50, but a negative association afterwards.
HDL levels consistently improved with higher 25(OH)D levels in all age groups, demonstrating the strongest link in postmenopausal women. However, the other form, 1,25(OH)D, only positively associated with HDL in people over 50 and didn't show significant effects on LDL or total cholesterol in any age category.
Overall, we pointed out that elevated levels of 25(OH)D can contribute to better cholesterol profiles, marked by lower levels of LDL and total cholesterol as well as higher HDL levels. This effect was particularly notable in those over 50 and postmenopausal women, highlighting the potential role of vitamin D in managing cholesterol levels.
We discovered that higher levels of 25(OH)D are connected with lower LDL and total cholesterol levels across the board. This relationship was especially strong among men over 50. Interestingly, the pattern varied for women; they showed a positive correlation with LDL and total cholesterol before age 50, but a negative association afterwards.
HDL levels consistently improved with higher 25(OH)D levels in all age groups, demonstrating the strongest link in postmenopausal women. However, the other form, 1,25(OH)D, only positively associated with HDL in people over 50 and didn't show significant effects on LDL or total cholesterol in any age category.
Overall, we pointed out that elevated levels of 25(OH)D can contribute to better cholesterol profiles, marked by lower levels of LDL and total cholesterol as well as higher HDL levels. This effect was particularly notable in those over 50 and postmenopausal women, highlighting the potential role of vitamin D in managing cholesterol levels.
Read More
Most Useful Reviews
9
Effective treatment
9 people found this helpful
Works!!! The medication is effective! In October 2022, my husband had a Vitamin D test with a level of 14.5 ng/ml, marking a deficiency in our area. After a month of taking this drug, his level rose to 74 ng/ml. We plan to switch to 10,000 IU every five days after reaching 80 ng/ml. This "liposomal" formulation is particularly suitable for individuals with gastrointestinal issues, enhancing absorption! I appreciate the consistent 10,000 IU dosage that isn't common among manufacturers, coupled with the dark glass packaging. If you're seeking a quality outcome swiftly, with minimal risks or side effects, I wholeheartedly recommend this drug!!!
Read More
9
Rapid improvement
1 people found this helpful
Attention! This Vitamin D boosted my levels from low to nearly high in just two months!!! If you're hesitant because of the price, cast aside all doubts and order it immediately! Health is paramount. Wishing everyone good luck and a long life!
Read More
7.5
Consistent quality
1 people found this helpful
Very high-quality Vitamin D! It arrived well-packaged and is absorbed well in 10,000 IU doses. I regularly take it to maintain my levels and continuously order it, often with Vitamin K2. Its effectiveness is apparent after a month and it also supports immunity. I recommend this to everyone, especially those with a Vitamin D deficiency.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.4
- All Researches
9
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
Read More
9
We explored the impact of vitamin D3 on cholesterol levels, specifically in individuals taking olanzapine, an antipsychotic medication known to cause dyslipidemia, a condition characterized by abnormal lipid levels. By analyzing various sources including the FDA Adverse Event Reporting System and electronic medical records, we aimed to uncover whether vitamin D3 supplementation could alleviate the cholesterol imbalances caused by olanzapine.
Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.
Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.
In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
Our findings revealed that vitamin D3 has a beneficial effect, helping to reduce the unfavorable changes in cholesterol levels typically induced by olanzapine. In particular, we noted that while olanzapine raised low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol, vitamin D3 supplementation appeared to help restore balance in these lipid levels.
Further investigations into cellular mechanisms showed that vitamin D3 may work by inhibiting the cholesterol production process within certain cells. This aligns well with our overall goal of identifying effective treatment strategies that can positively affect cholesterol management in those affected by olanzapine treatment.
In summary, our comprehensive analysis suggests that vitamin D3 supplementation could serve as a promising adjunct therapy for managing cholesterol levels in patients prescribed olanzapine.
Read More
8
We investigated the relationship between serum levels of vitamin D and the risk of high cholesterol, or hyperlipidemia, among adults in a prospective cohort study. This research involved collecting data over three years to understand how vitamin D might influence cholesterol levels, particularly focusing on different ranges of vitamin D sufficiency.
Our findings indicated that individuals with low vitamin D levels faced a significantly higher risk of developing hyperlipidemia. Specifically, those deficient in vitamin D had over 1.5 times the risk compared to those with adequate levels of this essential vitamin.
Additionally, a notable percentage of participants were found to have vitamin D deficiency, particularly among middle-aged and older adults. This suggests a potential link between lifestyle factors accompanying low vitamin D levels and the increased likelihood of high cholesterol.
Overall, these insights point to the promising possibility of improving cholesterol profiles through adequate vitamin D intake, but further research is likely needed to develop clear treatment pathways based solely on vitamin D supplementation.
Our findings indicated that individuals with low vitamin D levels faced a significantly higher risk of developing hyperlipidemia. Specifically, those deficient in vitamin D had over 1.5 times the risk compared to those with adequate levels of this essential vitamin.
Additionally, a notable percentage of participants were found to have vitamin D deficiency, particularly among middle-aged and older adults. This suggests a potential link between lifestyle factors accompanying low vitamin D levels and the increased likelihood of high cholesterol.
Overall, these insights point to the promising possibility of improving cholesterol profiles through adequate vitamin D intake, but further research is likely needed to develop clear treatment pathways based solely on vitamin D supplementation.
Read More
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
Read More
8
We explored how ergosterol, a precursor of vitamin D, impacts cholesterol levels and vitamin D biosynthesis in ovariectomized (OVX) rats. Our study revealed that daily high ergosterol intake over 14 weeks significantly lowered plasma cholesterol levels, an important finding since high cholesterol can lead to various health issues.
Additionally, we found that treated OVX rats had higher levels of 7-dehydrocholesterol, a precursor to vitamin D, suggesting that ergosterol not only helps decrease cholesterol but may also promote improved vitamin D synthesis. We also observed a slight increase in the active form of vitamin D in these rats.
Perhaps most excitingly, ergosterol contributed to better bone strength, countering some of the effects of OVX-induced bone resorption. This suggests that ergosterol could be a promising option for addressing both dyslipidemia and osteoporosis in postmenopausal women, providing a dual benefit for health.
Overall, our findings support the idea that ergosterol could be an adjunct to traditional treatments for managing cholesterol and promoting vitamin D levels.
Additionally, we found that treated OVX rats had higher levels of 7-dehydrocholesterol, a precursor to vitamin D, suggesting that ergosterol not only helps decrease cholesterol but may also promote improved vitamin D synthesis. We also observed a slight increase in the active form of vitamin D in these rats.
Perhaps most excitingly, ergosterol contributed to better bone strength, countering some of the effects of OVX-induced bone resorption. This suggests that ergosterol could be a promising option for addressing both dyslipidemia and osteoporosis in postmenopausal women, providing a dual benefit for health.
Overall, our findings support the idea that ergosterol could be an adjunct to traditional treatments for managing cholesterol and promoting vitamin D levels.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective treatment
9 people found this helpful
Works!!! The medication is effective! In October 2022, my husband had a Vitamin D test with a level of 14.5 ng/ml, marking a deficiency in our area. After a month of taking this drug, his level rose to 74 ng/ml. We plan to switch to 10,000 IU every five days after reaching 80 ng/ml. This "liposomal" formulation is particularly suitable for individuals with gastrointestinal issues, enhancing absorption! I appreciate the consistent 10,000 IU dosage that isn't common among manufacturers, coupled with the dark glass packaging. If you're seeking a quality outcome swiftly, with minimal risks or side effects, I wholeheartedly recommend this drug!!!
Read More
9
Rapid improvement
1 people found this helpful
Attention! This Vitamin D boosted my levels from low to nearly high in just two months!!! If you're hesitant because of the price, cast aside all doubts and order it immediately! Health is paramount. Wishing everyone good luck and a long life!
Read More
7.5
Consistent quality
1 people found this helpful
Very high-quality Vitamin D! It arrived well-packaged and is absorbed well in 10,000 IU doses. I regularly take it to maintain my levels and continuously order it, often with Vitamin K2. Its effectiveness is apparent after a month and it also supports immunity. I recommend this to everyone, especially those with a Vitamin D deficiency.
Read More
7.5
Vitamin D improvement
6 people found this helpful
The only supplement that increased my vitamin D levels! For six years, I struggled to get above 29.7, possibly due to low stomach acidity. Just four days after starting this supplement, I tested again and my Vitamin D rose to 42.5! I'm out of the deficit now and aiming for at least 90. The supplement's quality is exceptional, and the ingredients are effective! I feel much better and the dosage is optimal. I'll re-evaluate soon and update my review.
Read More
Frequently Asked Questions
9
Effective treatment
9 people found this helpful
Works!!! The medication is effective! In October 2022, my husband had a Vitamin D test with a level of 14.5 ng/ml, marking a deficiency in our area. After a month of taking this drug, his level rose to 74 ng/ml. We plan to switch to 10,000 IU every five days after reaching 80 ng/ml. This "liposomal" formulation is particularly suitable for individuals with gastrointestinal issues, enhancing absorption! I appreciate the consistent 10,000 IU dosage that isn't common among manufacturers, coupled with the dark glass packaging. If you're seeking a quality outcome swiftly, with minimal risks or side effects, I wholeheartedly recommend this drug!!!
9
Rapid improvement
1 people found this helpful
Attention! This Vitamin D boosted my levels from low to nearly high in just two months!!! If you're hesitant because of the price, cast aside all doubts and order it immediately! Health is paramount. Wishing everyone good luck and a long life!
7.5
Vitamin D improvement
6 people found this helpful
The only supplement that increased my vitamin D levels! For six years, I struggled to get above 29.7, possibly due to low stomach acidity. Just four days after starting this supplement, I tested again and my Vitamin D rose to 42.5! I'm out of the deficit now and aiming for at least 90. The supplement's quality is exceptional, and the ingredients are effective! I feel much better and the dosage is optimal. I'll re-evaluate soon and update my review.
7.5
Consistent quality
1 people found this helpful
Very high-quality Vitamin D! It arrived well-packaged and is absorbed well in 10,000 IU doses. I regularly take it to maintain my levels and continuously order it, often with Vitamin K2. Its effectiveness is apparent after a month and it also supports immunity. I recommend this to everyone, especially those with a Vitamin D deficiency.
8
We investigated the relationship between serum levels of vitamin D and the risk of high cholesterol, or hyperlipidemia, among adults in a prospective cohort study. This research involved collecting data over three years to understand how vitamin D might influence cholesterol levels, particularly focusing on different ranges of vitamin D sufficiency.
Our findings indicated that individuals with low vitamin D levels faced a significantly higher risk of developing hyperlipidemia. Specifically, those deficient in vitamin D had over 1.5 times the risk compared to those with adequate levels of this essential vitamin.
Additionally, a notable percentage of participants were found to have vitamin D deficiency, particularly among middle-aged and older adults. This suggests a potential link between lifestyle factors accompanying low vitamin D levels and the increased likelihood of high cholesterol.
Overall, these insights point to the promising possibility of improving cholesterol profiles through adequate vitamin D intake, but further research is likely needed to develop clear treatment pathways based solely on vitamin D supplementation.
Our findings indicated that individuals with low vitamin D levels faced a significantly higher risk of developing hyperlipidemia. Specifically, those deficient in vitamin D had over 1.5 times the risk compared to those with adequate levels of this essential vitamin.
Additionally, a notable percentage of participants were found to have vitamin D deficiency, particularly among middle-aged and older adults. This suggests a potential link between lifestyle factors accompanying low vitamin D levels and the increased likelihood of high cholesterol.
Overall, these insights point to the promising possibility of improving cholesterol profiles through adequate vitamin D intake, but further research is likely needed to develop clear treatment pathways based solely on vitamin D supplementation.
8
Vitamin D improves triglycerides and HDL-C
We wanted to understand how vitamin D supplementation affects cholesterol levels, especially in women who are overweight or obese. Our analysis involved reviewing multiple randomized controlled trials, allowing us to look closely at the changes potential vitamin D can bring to lipid profiles.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
We found that taking vitamin D led to significant reductions in triglyceride levels and total cholesterol. Specifically, triglycerides dropped by about 6.13 mg/dL, while total cholesterol saw a decrease of 4.45 mg/dL. Interestingly, we also noticed that vitamin D supplementation was linked to an increase in levels of high-density lipoprotein cholesterol (HDL-C), which is often referred to as the "good" cholesterol.
However, it's worth noting that despite these positive changes, vitamin D did not significantly impact low-density lipoprotein cholesterol (LDL-C), often known as the "bad" cholesterol. Therefore, while vitamin D can help with some lipid profile issues, its effect on LDL-C isn’t as pronounced.
Overall, we are encouraged by the results indicating that vitamin D can play a beneficial role in managing triglycerides and cholesterol levels among overweight or obese women, but we acknowledge that more research is needed to fully understand its effects on LDL-C.
9
We investigated how vitamin D3 supplementation impacts cholesterol levels in pediatric patients with obesity. During our study, we divided 723 children into two groups: one received vitamin D3 supplements, while the other received a placebo. This allowed us to comprehensively assess the relationship between vitamin D and metabolic health, especially focusing on high cholesterol.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
What we found was promising. After introducing vitamin D3 to the participants, we observed a significant drop in various lipid levels among those who received the supplements compared to those who were on the placebo. Specifically, there were notable reductions in total cholesterol, triglycerides, and low-density lipoprotein (LDL), alongside improvements in high-density lipoprotein (HDL).
Our results highlight that vitamin D3 not only boosted vitamin D levels but also positively influenced cholesterol metabolism. This suggests that supplementing with vitamin D could be a helpful strategy for managing high cholesterol, particularly in children struggling with obesity. Overall, our findings underscore the potential of vitamin D in improving metabolic health in younger populations.
8
Vitamin D improves cholesterol levels
In a recent double-blind, randomized clinical trial, we explored how vitamin D treatment affects cholesterol levels in patients with ischemic heart disease, a condition often linked with high cholesterol and vitamin D deficiency.
In this study, 44 patients aged 40 to 65 who were suffering from low vitamin D levels were divided into two groups. One group received vitamin D supplements while the other got a placebo. We carefully measured their cholesterol levels and C-reactive protein (CRP), which serves as an inflammation marker, before and after the treatment.
Our findings were promising. Patients in the vitamin D group experienced a significant increase in their high-density lipoprotein cholesterol (HDL-C), often referred to as the "good" cholesterol. Additionally, their triglyceride (TG) levels decreased, which is a positive outcome for heart health. Although there was an observed increase in HDL levels within the placebo group as well, the vitamin D group's improvements were more pronounced, suggesting beneficial effects from the treatment.
However, it’s worth noting that the relationship between vitamin D treatment and CRP levels didn’t show significant improvement. Overall, our study suggests that vitamin D may play a beneficial role in managing cholesterol levels in ischemic heart disease patients, providing an additional avenue for healthcare management these individuals.
In this study, 44 patients aged 40 to 65 who were suffering from low vitamin D levels were divided into two groups. One group received vitamin D supplements while the other got a placebo. We carefully measured their cholesterol levels and C-reactive protein (CRP), which serves as an inflammation marker, before and after the treatment.
Our findings were promising. Patients in the vitamin D group experienced a significant increase in their high-density lipoprotein cholesterol (HDL-C), often referred to as the "good" cholesterol. Additionally, their triglyceride (TG) levels decreased, which is a positive outcome for heart health. Although there was an observed increase in HDL levels within the placebo group as well, the vitamin D group's improvements were more pronounced, suggesting beneficial effects from the treatment.
However, it’s worth noting that the relationship between vitamin D treatment and CRP levels didn’t show significant improvement. Overall, our study suggests that vitamin D may play a beneficial role in managing cholesterol levels in ischemic heart disease patients, providing an additional avenue for healthcare management these individuals.
References
- Liu ZY, Liu S, Yao X, Wang CY, Song Y, et al. A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults. Front Nutr. 2024;11:1492621. 10.3389/fnut.2024.1492621
- Hu L, Velu P, Prabahar K, Hernández-Wolters B, Kord-Varkaneh H, et al. Effect of Vitamin D Supplementation on Lipid Profile in Overweight or Obese Women: A Meta-analysis and Systematic Review of Randomized Controlled Trials. Nutr Rev. 2025. 10.1093/nutrit/nuae226
- Kuwabara N, Kanda J, Sato S, Nakagawa S. Impact of Daily High Ergosterol Intake for 14 Weeks in Ovariectomized Rats on Cholesterol and Vitamin D Biosynthesis Pathways. Biol Pharm Bull. 2025;48:39. 10.1248/bpb.b24-00536
- Wang F, Bei L, Zhang X, Fu Y. Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity. Crit Rev Immunol. 2025;45:31. 10.1615/CritRevImmunol.2024052129
- Li X, Liu Y, Wang J, Chen X, Reichetzeder C, et al. Vitamin D Is Associated with Lipid Metabolism: A Sex- and Age-Dependent Analysis of a Large Outpatient Cohort. Nutrients. 2024;16. 10.3390/nu16223936
- Hu T, Zhang Y, Chen Z, Su J. Relationship between serum vitamin D levels and the atherogenic index of plasma: a study based on NHANES database 2011-2018. Front Nutr. 2024;11:1468284. 10.3389/fnut.2024.1468284
- Xu H, Qiu S, Lin P, Liao X, Lin Y, et al. Vitamin D has therapeutic effects on obesity and hyperandrogenemia in PCOS mouse model induced by low dose DHEA and high-fat diet. BMC Womens Health. 2024;24:601. 10.1186/s12905-024-03445-w
- Sadeghi M, Momeni A, Mirsaeidi FS, Jamalian M, Amirpour A, et al. The Effect of Vitamin D Deficiency Treatment on Lipid Profile and C-reactive Protein in Patients with Ischemic Heart Disease: Double-blind Randomized Clinical Trial. Adv Biomed Res. 2024;13:79. 10.4103/abr.abr_380_23
- Wang J, Shi T, Xu L, Li Y, Mi W, et al. Correlation between hyperlipidemia and serum vitamin D levels in an adult Chinese cohort. Front Nutr. 2024;11:1302260. 10.3389/fnut.2024.1302260
- Xu W, Wang L, Yang L, Li X, Li C, et al. [Vitamin D3 alleviates the gastritis that associated with Helicobacter pylori infection in mice with hypercholesterolemia by enhancing the activity of vitamin D receptors in the liver tissue and blocking the signaling pathway of JAK/STAT3]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2024;40:520.
- Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. 10.3390/nu16091331
- Oczkowicz M, Szymczyk B, Świątkiewicz M, Wierzbicka A, Steg A, et al. Effect of vitamin D3 supplementation on blood parameters and liver gene expression in female rats. Mol Biol Rep. 2024;51:456. 10.1007/s11033-024-09408-6
- Yang HE, Lee BW, Choi IJ, Oh JY, An EJ. Age-dependent effect of vitamin D supplementation on musculoskeletal health in chronic spinal cord injury patients: A pilot study. J Spinal Cord Med. 2025;48:93. 10.1080/10790268.2023.2257850
- Habiba E, Ali S, Ghanem Y, Sharaki O, Hewedy W. Effect of oral versus parenteral vitamin D3 supplementation on nuclear factor-κB and platelet aggregation in type 2 diabetic patients. Can J Physiol Pharmacol. 2023;101:610. 10.1139/cjpp-2022-0359
- Sandgruber F, Höger AL, Kunze J, Schenz B, Griehl C, et al. Impact of Regular Intake of Microalgae on Nutrient Supply and Cardiovascular Risk Factors: Results from the NovAL Intervention Study. Nutrients. 2023;15. 10.3390/nu15071645
- Zhou Z, Nagashima T, Toda C, Kobayashi M, Suzuki T, et al. Vitamin D supplementation is effective for olanzapine-induced dyslipidemia. Front Pharmacol. 2023;14:1135516. 10.3389/fphar.2023.1135516
- Hariri Z, Kord-Varkaneh H, Alyahya N, Prabahar K, Găman MA, et al. Higher Dietary Vitamin D Intake Influences the Lipid Profile and hs-CRP Concentrations: Cross-Sectional Assessment Based on The National Health and Nutrition Examination Survey. Life (Basel). 2023;13. 10.3390/life13020581
